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Articles

Chemical Genetics in C. elegans Identifies Anticancer Mycotoxins Chaetocin and Chetomin as Potent Inducers of a Nuclear Metal Homeostasis Response

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By Elijah Abraham, Kalina R Atanasova, Qi-Yin Chen, Taylor Corcoran
| dx.doi.org
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Chem. Biol. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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Chemical genetics in C. elegans identifies anticancer mycotoxins chaetocin and chetomin as potent inducers of a nuclear metal homeostasis response

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By Elijah Abraham, Kalina R Atanasova, Qi-Yin Chen, Taylor Corcoran
| BioRxiv
Abstract C. elegans numr-1/2 (nuclear-localized metal-responsive) is an identical gene pair encoding a nuclear protein previously shown to be activated by cadmium and disruption of the integrator RNA metabolism complex. We took a chemical genetic approach to further characterize regulation of this novel metal response by screening 41,716 compounds and extracts for numr-1p::GFP activation.
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