Hypertension (HTN) impacts millions of Americans, driving the incidence of major sequelae such as stroke, myocardial infarction, and renal failure and accounting for an estimate of > $200 billion of health care spending annually.1 Resistant HTN, defined as blood pressure that is uncontrolled despite three or more antihypertensive medications of different classes, is not only a prevalent condition (affecting 8.5% to 20% of hypertensive American adults) but also one that is highly costly.2...