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Articles

Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs

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By Xiaoyan Wu, Adrian Watson, Hille Fieten, TCCI Consultancy BV
| pericles.pericles-prod.literatumonline.com
Abstract Background Hepatic copper accumulation causes chronic hepatitis in dogs. Mutations in the copper transporters ATP7A and ATP7B were, respectively, associated with attenuation and enhancement of hepatic copper concentrations in Labrador Retrievers. There is a predisposition of Dobermanns to hepatitis with increased hepatic copper concentrations.
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Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs - Wu - - Journal of Veterinary Internal Medicine - Wiley Online Library

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By Xiaoyan Wu, Adrian Watson, Hille Fieten, TCCI Consultancy BV
| Wiley Online Library Verified
Abstract Background Hepatic copper accumulation causes chronic hepatitis in dogs. Mutations in the copper transporters ATP7A and ATP7B were, respectively, associated with attenuation and enhancement of hepatic copper concentrations in Labrador Retrievers. There is a predisposition of Dobermanns to hepatitis with increased hepatic copper concentrations.
Open in Who Shared Issue with article?

Gene expression patterns in the progression of canine copper-associated chronic hepatitis

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By Karen Dirksen, Bart Spee, Louis C. Penning, TCCI Consultancy BV
| PLOS
Copper is an essential trace element, but can become toxic when present in abundance. The severe effects of copper-metabolism imbalance are illustrated by the inherited disorders Wilson disease and Menkes disease. The Labrador retriever dog breed is a novel non-rodent model for copper-storage disorders carrying mutations in genes known to be involved in copper transport.
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