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Ted Barrett

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Articles

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

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By Ted Barrett, Sakshi Bhargava, Kalpana Merchant, Dianne K. Bryce
| Science Magazine Verified
Parsing the side effects of LRRK2 inhibitors Preclinical studies have raised concerns about the safety of LRRK2 inhibitors—developed for treating Parkinson’s disease—specifically regarding lung function. Baptista et al. now report that several different LRRK2 inhibitors induce on-target histopathological changes in the lungs of nonhuman primates.
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