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Articles by Ted Lain
OTC Skincare: How Much Do You Know?
By Patricia Farris, MD, and Ted Lain, MD, MBA More than ever, we are using over-the-counter topical skincare to treat our patients. This is, in part, due to the reluctance of insurers to pay for prescription topical therapies. It is also the result of a growing number of effective treatment options that are now available over the counter.
Resources for Patients With Vitiligo
Heather Woolery-Lloyd, MD: What types of resources are available to our vitiligo patients? Ted Lain, MD: Until recently, we didn’t have great resources. If you just Google Vitiligo Foundation, you will find resources like the Global Vitiligo Foundation, the vitiligo support group, the National Vitiligo Foundation. Ruxolitinib has really come out with some good educational material on their website.
Advice for Physicians Treating Patients With Vitiligo
Heather Woolery-Lloyd, MD: This is one question that I am dying to ask you because I want to be a better doctor. What advice would you give doctors who are treating patients with vitiligo? Tarasha: Don’t do what my dermatologist did and give minimal information. If it is something that you know about, give all of the information to a patient that you possibly can. Don’t minimalize it. Tell them the risk from good to bad, from high to low, and everything in between. Don’t skim over anything.
Importance of Support for Patients With Vitiligo
Heather Woolery-Lloyd, MD: Tarasha, I want to talk to you about your journey. How did your friends and family react and support you when you got this diagnosis? Tarasha: It was a shock to a lot of people. Recently I went to one of my sorority’s events, and I hadn’t seen one of my friends in 3 or 4 years.
Use of Ruxolitinib for Vitiligo Treatment
Heather Woolery-Lloyd, MD: Topical ruxolitinib cream is FDA-approved for nonsegmental vitiligo. How does the product work? Ted Lain, MD: It is a topical JAK [Janus kinase] inhibitor. JAK inhibitors are intracellular small molecule medications. They work inside the cell to block the effects of interferon on the keratinocyte or on the melanocyte.
Treatment Options for Vitiligo
The Vitiligo Patient Journey - Episode 4 Ted Lain, MD, reviews the current treatment landscape for vitiligo, highlighting topical ruxolitinib as a major advancement. Heather Woolery-Lloyd, MD: Vitiligo is luckily gaining a lot of attention and research. It’s an exciting time for vitiligo. What treatment options do you consider? Is there a standard of care when it comes to treating our vitiligo patients? Ted Lain, MD: Until recently, there wasn’t a standard of care because nothing was FDA-approved.
Treatment Approaches to Vitiligo and Patient/Physician Communication
Heather Woolery-Lloyd, MD: Tarasha, what treatments have you gotten for your vitiligo? I know you said that you opted not to do treatments. But what treatments were recommended by your doctor? Tarasha: Topical cream. That is the only thing. I am sitting here shocked because tests were not run on me when I went to the dermatologist, or even to my primary care doctor. They never ran tests on me to see if anything else was going on with my immune system. Nobody ever ran any type of test.
Considerations for Evaluating Patients With Vitiligo
Heather Woolery-Lloyd, MD: Now I want to talk Dr Lain. How do you approach your patients with vitiligo? When a patient is referred to you for vitiligo, how do you evaluate them? Do you do certain tests? Tell me what you do with your patients. Ted Lain, MD: Thanks, Heather. First, can we please acknowledge how brave Tarasha is. I mean, for her to come on this. Tarasha and I know each other, and she was so gracious and offered to volunteer for this.
Patient Journey to Diagnosis of Vitiligo
Heather Woolery-Lloyd, MD: Hello, and thank you for joining this HCPLive® CURE Connections program titled “The Vitiligo Patient Journey.” Vitiligo is a skin disorder that results in the loss of pigmentation in the skin and hair. Vitiligo can significantly impact the quality of life of those affected, often leading to emotional distress and stigma.
Key Takeaways on Vitiligo Management
Seemal Desai, MD: So, this has been a tour de force of an amazing discussion. In the last few minutes let's get some sort of final parting thoughts and, really, I would love to have your thoughts about where we are in our disease state understanding, anything we talked about clinically, and kind of your hopes and dreams for the future of this disease and, really, for skin disease. We know that there are so many skin diseases out there that we treat that don't have FDA-approved therapies.
Promoting Access to New Therapies in Vitiligo
Seemal Desai, MD: So, Ted, we talked about access to therapy and wanting for clinicians and dermatologists to be able to get new treatments in the hands of their patients. Talk to me about some tips, tricks; ways that you've been able to motivate your patients and what can we share with our colleagues on access to therapies and how they can get some of these? Ted Lain, MD: I really think it all starts with documentation in the progress note.
Managing Vitiligo Patient Expectations
Restoring Skin Pigmentation in Vitiligo With Advanced Treatments - Episode 13 Published on: Seemal R. Desai, MD, Heather Woolery-Lloyd, MD, Brittany G. Craiglow, MD, Nada Elbuluk, MD, MSc, FAAD, Ted Lain, MD Heather Woolery-Lloyd, MD, and Nada Elbuluk, MD, share approaches to patient education and managing patient expectations when repigmenting the skin in vitiligo. Seemal Desai, MD: Heather, patient education and counseling: I know you’re very passionate about really educating the patient.
Disease Burden for Patients With Vitiligo
Seemal Desai, MD: This has been a phenomenal discussion. We’ve talked about pathophysiology, we talked about treatment, data, and safety. So, let’s round over to home base and talk a little bit about just promoting compliance and adherence, and that patient experience and patient journey. Brittany, I’m going to start with you, and Ted, I want you to chime in here as well. We talked about conventional treatments for vitiligo.
Treatment Response to Conventional vs Emerging Therapies in Vitiligo
Restoring Skin Pigmentation in Vitiligo With Advanced Treatments - Episode 11 Published on: Seemal R. Desai, MD, Heather Woolery-Lloyd, MD, Brittany G. Craiglow, MD, Nada Elbuluk, MD, MSc, FAAD, Ted Lain, MD Nada Elbuluk, MD, and Ted Lain, MD, compare response to conventional treatment options vs emerging therapies, such as ruxolitinib, in the treatment of vitiligo.
Treatment Approaches to Ruxolitinib in Vitiligo
Seemal Desai, MD: We’ve heard all the data. I’d love to get everyone’s feeling on initial impressions from the finding and how ruxolitinib has changed your practice in terms of your first-line topical therapy vs others. Heather Woolery-Lloyd, MD: I’ll start because it has changed my practice. I’ve been practicing for 20 years, so I’ve had patients with vitiligo for 20 years.
Adverse Events of Ruxolitinib in Vitiligo Trials
Seemal Desai, MD: Let’s go back to the study. Let’s get back on task because I want to focus on the remainder of the data. Heather, talk about adverse events. Safety is so important. Talk to me a little about the TRuE-V1 and TRuE-V2 adverse event [AE] profile and anything you pull from that when you counsel your patient. Heather Woolery-Lloyd, MD: The adverse event profile is great. I call myself a safety nerd. I really care about safety. To me, it’s just as important as efficacy.
Impact of UV Light Exposure on Vitiligo
Seemal Desai, MD: Brittany, you mentioned response rates. We talked about the difficulty in other sites. What are your thoughts on why the body pigmentation lagged behind the facial repigmentation? Do you agree with Ted’s comments? Brittany Craiglow, MD: Yes. It has a lot to do with follicle density, but I also think ambient UV [ultraviolet] light. We’re all walking around. What’s getting light every day? Even in Connecticut, where I’m wearing a jacket, I’m getting light on my face.
Use of Ruxolitinib for Treatment of Vitiligo
Seemal Desai, MD: We know that we are for the first time ever, in the history of this disease, just 8 months ago, have the first-ever FDA-approved therapy to repigment vitiligo. We’ve never had any therapy to make this disease better. Ironically, the fun fact for any residents—and I love doing this, giving a true or false.
Mechanism of Repigmentation in Vitiligo
Restoring Skin Pigmentation in Vitiligo With Advanced Treatments - Episode 5 Mechanism of Repigmentation in Vitiligo April 26, 2023 Seemal R. Desai, MD, Heather Woolery-Lloyd, MD, Brittany G. Craiglow, MD, Nada Elbuluk, MD, MSc, FAAD, Ted Lain, MD Ted Lain, MD, reviews the rates and patterns of repigmentation of the skin in vitiligo and how the timeline is different for each patient.
Treatment Goals in Vitiligo
Seemal Desai, MD: I love that we talked about quality of life, but let’s tie that into now treatment goals. How does quality of life and outlook tie into the patient’s treatment goals, versus your treatment goals as the doctor? And how do you do that shared decision-making? Because I think this is a really interesting dynamic in vitiligo. Heather Woolery-Lloyd, MD: It is.
Quality of Life for Vitiligo Patients
Seemal Desai, MD: Heather, speaking of patients and their perception, let’s talk a bit about quality of life. I know you’re very passionate about that topic. I know you’ve spoken on that before, you do a lot on social media to educate and empower patients. Tell me how you approach talking about quality of life with a patient with vitiligo, because many in the health care world think vitiligo is benign, it’s simply cosmetic. But the patient suffering doesn’t feel like that.
Assessment of Vitiligo Severity
Seemal Desai, MD: I appreciate you mentioning active and unstable vitiligo. I want to come back to that in just a minute, and I think that’s a good segue, Ted, because you’ve been involved in clinical trials in your practice. You and I have done a lot of these together. Nada just talked a lot about unstable, inflammatory vitiligo, and the question is: How do we assess vitiligo? How do we grade it? How do we measure it?
Prevalence of Vitiligo
Seemal Desai MD: Hello and welcome to this HCPLive® Peer Exchange titled, “Restoring Skin Pigmentation in Vitiligo With Advanced Treatments.” It’s a pleasure to be here today with my esteemed colleagues. I’m Seemal Desai, I‘m a board-certified dermatologist in private and academic practice in Dallas, Texas, and on the faculty at UT [University of Texas] Southwestern Medical Center.
Burnout: Is Personal Happiness the Answer?
Podcast | January 9, 2023 The Practical Dermatology Podcast There’s no paucity of studies for biologic therapies used to treat psoriatic disease, but the number of head-to-head trials comparing these agents is limited. Enter network meta-analysis, a statistical methodology that has emerged over the past few years to compare medication.
ASLMS New Beginnings Initiative
Podcast | January 9, 2023 The Practical Dermatology Podcast There’s no paucity of studies for biologic therapies used to treat psoriatic disease, but the number of head-to-head trials comparing these agents is limited. Enter network meta-analysis, a statistical methodology that has emerged over the past few years to compare medication.
Advancing Digital Medicine in Dermatology
Podcast | November 13, 2022 The Practical Dermatology Podcast The Digital Medicine Society (DiME) is a global nonprofit dedicated to advancing the ethical, effective, equitable, and safe use of digital medicine to redefine health care and improve lives. DiME recently released a new set of resources, available at www.dimesociety.org/access-resources/, to advance the use of digitally measured nocturnal scratch as a meaningful endpoint for atopic dermatitis.
Revance Shares Two Publications in The Aesthetic Surgery Journal That Advance Glabellar Line Injection Technique and Assessment
Two peer-reviewed articles in the Aesthetic Surgery Journal, the official journal of The Aesthetic Society, highlight the nuances of glabellar line injection technique and aim to improve patient outcomes, irrespective of the neuromodulator used.
Meet Crown’s ProGen PRP Eclipse
Crown Aesthetics completed the rebranding of ProGen PRP Advantage, now renamed ProGen PRP Eclipse. ProGen PRP Eclipse is a one-spin system that features 15 mL and 30 mL tubes, yielding 7-15 mL of Platelet Rich Plasma. "Crown's commitment to best-in-class service, advanced skincare treatments, product development, and safety and efficacy is unyielding," says Mike Zuccala, Global Vice President, Marketing for Crown Aesthetics., in a news release.
Hydrafacial and Glytone Team Up to Launch New Booster
The Beauty Health Company’s Hydrafacial is rolling out a new exfoliating booster co-created with Glytone. The Glytone AHA Resurfacing Cellular Booster leverages a unique combination of three alpha hydroxy acids (AHAs) that may help improve the appearance of skin surface and texture to provide a radiant, glowing complexion. The booster will launch at providers nationally in the U.S. beginning November 9th.
November is Hyperhidrosis Awareness Month
November is Hyperhidrosis Awareness Month and the International Hyperhidrosis Society (IHhS) is committed to raising awareness of this medical condition that affects 365 million people worldwide, of which 27 percent go undiagnosed. In the United States alone, more than 15 million Americans have hyperhidrosis (approximately 5% of the population), but many of those dealing with the condition fail to recognize it as a medical issue and only 51 percent discuss it with their physicians.
Merz’s Xeomin Taps Teyana Taylor as Brand Partner
Teyana Taylor is the latest brand partner for Merz’z Xeomin (incobotulinumtoxinA). The U.S. partnership is a continuation of the ‘Beauty on Your Terms’ campaign for Xeomin, an FDA-approved double filtered anti-wrinkle injection to temporarily improve the appearance of frown lines with only the ingredients that work and none that don’t.
A Peak Inside the Psoriasis Pipeline
The evolution and revolution in understanding the psoriasis pathway of inflammation has ushered in amazing new treatments that are highly effective at clearing plaque psoriasis. Multiple biologics and new oral and topical non-steroidal medications continue to expand the treatment options available to physicians and patients. Here, I take a closer look at the latest research findings on existing therapies and bring you up to date on new and emerging treatments.
Next Generation Environmental Protection: Antioxidants and Chelators
Despite our best efforts as dermatologists to encourage sun protection, the incidence of skin cancer continues to rise in the US. In addition, there is an insatiable desire by consumers to prevent the signs of skin aging, including fine lines and wrinkles, mottled pigmentation, and brown spots.
Hair Straightening Chemicals Associated with Higher Uterine Cancer Risk
Chemical hair straighteners may be contributing to a rise in aggressive uterine cancers a new study in the Journal of the National Cancer Institute suggests. There were no associations with uterine cancer for other hair products that the women reported using, including hair dyes, bleach, highlights, or perms.
Potential Hair Growth Breakthrough: Researchers Grow Mature Hair Follicles in Lab
Japanese researchers have successfully grown hair follicles in the lab. The team created a system that produces fully mature hair follicles as well as hair as long as 3 millimeters after a few weeks' growth. The in vitro hair follicle model adds to the understanding of hair follicle development which could contribute to development of useful applications in treating hair loss disorders, animal testing, and drug screenings. The system relies on organoids.
Targeting Cellulite: Evolving Approaches
Affecting up to 90% of female adults, cellulite is a significant aesthetic concern that has been associated with systemic associations and a negative psychological impact on affected patients.1 Over the past several years, therapeutic advancements have offered new options for the treatment of cellulite—welcome for a large market with significant unmet needs.
Game Changer: Incyte’s Ruxolitinib Reverses Vitiligo - Practical Dermatology
Topical Ruxolitinib is highly effective for skin re-pigmentation in vitiligo, according to Phase III clinical trial results published in The New England Journal of Medicine. The study showed better than 75 percent improvement on face and 50 percent improvement on body for half of all patients in study.
Maximizing Results: The Benefits of Biostimulators
Patients often present with a desire for optimal results on a limited budget. Sabrina Fabi, MD shares how she effectively uses biostimulators in her practice. For low-volume, high-yield results, she recommends 1 vial every 8 months to a year. Alternating this with hyaluronic acid fillers, keeps everything “high and tight” for her patients.
Tips for Success with Fillers
Heidi Waldorf, MD offers tips for getting the best results possible with fillers. From how to evaluate what patients need to considering shapes and proportions, she offers hands-on advice to help achieve optimal outcomes. Plus, she discusses the importance of managing patient expectations.
Lasers and EBDs: Considerations for Ethnic Skin
Monica Li, MD reviews evidence-based practices for using lasers, energy-based devices and minimally invasive procedures to manage benign dermatoses to treat patients with skin of color. She discusses the importance of engaging patients in appropriate pre- and post-treatment care to reduce potential adverse effects such as post-inflammatory pigmentation and keloid scars.
Curtis Cluff Named President and CFO of BioPhotas Inc.
Curtis Cluff is the new President and Chief Financial Officer BioPhotas Inc., manufacturers of the Celluma series of light therapy devices. In this newly created role, Mr. Cluff will report to Patrick Johnson, Chief Executive Officer and inventor of the Celluma. "Curtis brings more than 20 years of industry leadership experience building or creating several successful aesthetic medical and consumer skincare brands,” says Johnson in a news release.
Right to Repair: How Developments Could Affect Aesthetics Practices
Recent action on the federal level has renewed interest in “Right to Repair” legislation, and the medical aesthetics industry is eyeing developments that might directly impact aesthetic practices and medspas. Right to Repair legislation dates back to the 1970s, and most Americans are familiar with the concept as it relates to automobiles, notes Madison Dini, JD, commercial and business litigation attorney at Michelman & Robinson.
Business News: Incyte Buys Startup Villaris
Incyte will pay $70 million upfront to buy Villaris Therapeutics, a startup working on an experimental drug for vitiligo. Villaris’ lead asset, auremolimab (VM6), an anti-IL-15Rβ monoclonal antibody (mAb), is expected to enter clinical development in 2023. Villaris an asset-centric biopharmaceutical company seeded by Medicxi.
BeautyHealth’s Hydrafacial Teams Up with JLo
The BeautyHealth Company is rolling out the Hydrafacial x JLo Beauty Booster. “I'm so excited to partner with Hydrafacial to create the new JLo Beauty Booster,” says founder of JLo Beauty Jennifer Lopez in a news release. “Hydrafacial is one of my favorite treatments that helps me maintain my glow, so it makes sense that we would come together.
Power Move: UFC Performance Institute to Use Lutronic Accufit for Training, Rehab
Lutronic's Accufit will now be made available for use to UFC fighters and other elite athletes through the UFC Performance Institute. "Accufit provides a higher energy multi-dimensional muscle workout, and the body contouring iprovement is dramatic. This 3rd generation intelligent technology helps patients define their muscles without the gym," says Anne Chapas, MD, a dermatologist at Union Derm NY in New York City, in a news release.
Johnson & Johnson Announces Kenvue as the Name for New Consumer Health Company - Practical Dermatology
Johnson & Johnson’s planned new consumer health company will be named...Kenvue. Kenvue (pronounced ken·view), is inspired by two powerful ideas: “ken” – meaning knowledge, an English word primarily used in Scotland, and “vue,” referencing sight. With rich knowledge of human needs and deep consumer insights, Kenvue will deliver meaningful, personal health solutions, the company explains.
L'Oréal USA to Open New Research & Innovation Center in New Jersey
L'Oréal USA is opening a new, state-of-the-art Research & Innovation (R&I) Center in Clark, New Jersey, replacing its existing facilities that it has occupied in the area for more than six decades. The $140 million development project represents the most significant investment in an R&I facility in the company's history.
Peri-Procedural Skincare: A Look at the Evidence
Integrated Skincare refers to the use of clinically proven topical skincare in combination with procedures.
BTL Introduces EMFACE
BTL is taking on the minimally invasive facial aesthetic category with the launch of EMFACE. Emface simultaneously emits both synchronized radio frequency and HIFES-brand energies. The homogenous radiofrequency heats collagen and elastin fibers while the HIFES stimulation emits thousands of pulses per session to contract delicate facial muscles. The recommended treatment course for the EMFACE therapy calls for four 20-minute sessions, with each session completed 2-14 days apart.
Baby Dove Doubles Down Efforts to Close the Maternal Care Gap with #DearDoula and Greater Investment in Black Birth Equity Fund
Baby Dove is expanding the Black Birth Equity Fund, launching a new informative series called #DearDoula, and reinforcing existing strategic partnerships to help close the significant gap in care and health outcomes for Black mothers and their babies. "As a brand that encourages all parents to care with confidence, we are committed to making care for Black moms accessible and equitable," says Neha Minj, Brand Director and Head of Operations & Engagement for Baby Dove, in a news release.
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