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Teisuke Takita

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Articles

Room‐temperature X‐ray data collection enabled the structural determination of statin‐bound CYP105A1

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By Kaori Yasuda, Kimihiko Mizutani, Teisuke Takita, Sachiyo Yoneda
| Wiley Online Library Verified
Streptomyces griseolus CYP105A1 exhibits monooxygenase activity towards a wide variety of structurally diverse substrates with regiospecificity and stereospecificity, making it suitable for broad applications. Our previous studies have demonstrated that both wild-type CYP105A1 and its mutants metabolize vitamin D3 and its derivatives, as well as 12 types of nonsteroidal anti-inflammatory drugs (NSAIDs) and statins.
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