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Articles by Tej Sharma
Ebola Virus Matrix Protein VP40 Single Mutations G198R and G201R Significantly Enhance Plasma Membrane Localization
1. Introduction Click to copy section linkSection link copied! Viruses are capable of undergoing numerous genetic mutations, which can give rise to highly efficient variants with epidemic and pandemic potential. Ebola virus is one of the deadly viruses accounting for thousands of deaths and a 60 to 90% fatality rate. (1−6) The virus’ genome encodes for seven structural proteins, and genetic sequencing during the outbreak revealed several naturally occurring mutations in these proteins.
Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation
1 INTRODUCTION The Ebola virus (EBOV) was discovered in 1976 near the Ebola River in the Democratic Republic of Congo (formerly Zaire) (Brès, 1978). Since that time, sporadic outbreaks of EBOV have occurred, causing severe disease and often high fatality rates (Sivanandy et al., 2022).
Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles
Abstract Ebola virus (EBOV) is a filamentous negative-sense RNA virus which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is important to get a detailed understanding of the virus lifecycle to illuminate new drug targets. EBOV encodes for the matrix protein, VP40, which regulates assembly and budding of new virions from the inner leaflet of the host cell plasma membrane (PM).
Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles
Abstract Ebola virus (EBOV) is a filamentous negative-sense RNA virus which causes severe hemorrhagic fever. There are limited vaccines or therapeutics for prevention and treatment of EBOV, so it is important to get a detailed understanding of the virus lifecycle to illuminate new drug targets. EBOV encodes for the matrix protein, VP40, which regulates assembly and budding of new virions from the inner leaflet of the host cell plasma membrane (PM).
IJMS | Free Full-Text | Distinctive Features of the XBB.1.5 and XBB.1.16 Spike Protein Receptor-Binding Domains and Their Roles in Conformational Changes and Angiotensin-Converting Enzyme 2 Binding
Open AccessArticle by 1, 1,2 and 1,2,* 1 Department of Physics, Florida International University, Miami, FL 33199, USA 2 Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA * Author to whom correspondence should be addressed. Int. J. Mol. Sci.
April final exam period shortened by one week
Western’s April final examination period has been shortened by one week as a result of the extended winter break that delayed the start of the term. The exam period will now run from April 10 to 30, six days shorter than the original start date of April 4.
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