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Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects
MATERIALS AND METHODS Eligible subjects were healthy males or females aged 18–45 years with a weight ≥50.0 kg for males and ≥45.0 kg for females and a body mass index of 19.0–26.0 kg/m2. Subjects with, but not limited to, central nerve/psychiatric disorders and respiratory, cardiovascular, gastrointestinal, hematological, and endocrine disorders, which were considered clinically significant in the study, were excluded.
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