Terin D'Amico

ACN acetonitrile ArNASA N-acyl-N-aryl sulfonamide ATP adenosine triphosphate DCM dichloromethane DIPEA N N-diisopropylethylamine DMSO dimethylsulfoxide FP fluorescence polarization HCl hydrochloric acid Hsp90 90-kDa heat shock protein Lys58 lysine 58 MeOH methanol NASA N-acyl-N-alkyl sulfonamide PPIs protein–protein interactions SuFEx sulfur (VI) fluoride exchange TCI targeted covalent inhibitor TEA triethylamine 1 Introduction Recent advances in targeted covalent inhibitors (TCIs) have...

Hsp90β Heat shock protein 90 beta IAP Inhibitor of apoptosis protein IC50 Half-maximal inhibitory concentration IL-1β Interleukin 1 beta IL-8 Interleukin 8 KD Dissociation constant LC Laryngeal carcinoma LPS Lipopolysaccharide LR Linker region LRP-1 Lipoprotein receptor-related protein 1 MAPK Mitogen-activated protein kinase MD Middle domain MDR Multidrug resistance MEEVD Met-Glu-Glu-Val-Asp (conserved Hsp90 sequence) Mip-90 Microtubule-interacting protein 90 MM Multiple myeloma MMP3 Matrix...