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Articles

"Synthesis of Bacterial Surface Glycans for Conjugate Vaccines" by Teron D. Haynie

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By Teron Haynie, Brigham Young
| scholarsarchive.byu.edu
Home > Theses and Dissertations > 8669 Abstract Bacteria are coated with repeating units of oligosaccharides that exhibit remarkable diversity. Often, glycan units of three or even two sugars are sufficient to identify a species of bacteria. Such specificity makes bacterial surface glycans attractive vaccine targets.
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"Synthesis of Candidate Natural Killer T Cell Ligands" by Teron Haynie, Shenglou Deng et al.

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By Shenglou Deng, Paul Savage, Brigham Young, Teron Haynie
| scholarsarchive.byu.edu
Natural Killer T (NKT) cells are a subset of T cells that express an invariant T cell receptor (TCR) that recognizes lipid antigens in context of the CD1d molecule. CD1d presents both exogenous and endogenous glycolipids on the surface of antigen presenting cells (APCs). Multiple exogenous lipids capable of NKT cell stimulation have been characterized, but confirmed endogenous ligands are relatively few in number. Recently, a-galactosylceramides were shown to be endogenous NKT cell ligands.
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