Terrie G. Flatt on Muck Rack

Terrie G. Flatt

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Articles

Proof-of-concept study for the detection of somatic structural variant driver alterations using HiFi long-read sequencing in a pediatric leukemia cohort

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By Lisa A. Lansdon, Byunggil Yoo, Ayse G. Keskus, Irina Pushel, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Weijie Li, Linda D. Cooley, Elena A. Repnikova, Lei Zhang, Keith J. August, Alan S. Gamis, Erin Guest, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi, Chengpeng Bi, Mary Rindler, M. Habeebu, John Herriges, Terrie G. Flatt, J. Allyson Hays, Maxine Hetherington
| Nature Verified
Abstract Gene fusions are common primary drivers of pediatric leukemias and are the result of underlying structural variants (SVs). Current clinical workflows to detect such alterations rely on a multimodal approach, which often increases analysis time and overall cost of testing. In this study, we used long-read sequencing (lrSeq) as a proof-of-concept to determine whether clinically relevant (cr) SVs could be detected within a small (n = 17) pediatric leukemia cohort.
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