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Tevor Pugh on Muck Rack

Tevor Pugh

As seen in: Journal of Clinical Pathology
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Articles

T cell clonality assessment: past, present and future

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By Etienne Mahe, Tevor Pugh, Suzanne Kamel-Reid
| Journal of Clinical Pathology Verified
Lymphocyte maturation is a fascinating process marked by immunophenotypic changes, as well as discrete and regulated molecular events.1–3 For mature T cells, an important part of this molecular ‘evolution’ involves somatic alteration of the germline configuration of the T cell receptor (TCR) genes to a unique configuration, in order to permit development of a clone of T cells with an extracellular receptor specific to a given antigen.1–3 Modern diagnostic pathology has exploited the molecular...
Open in Who Shared Issue with article?

T cell clonality assessment: past, present and future

|
By Etienne Mahe, Tevor Pugh, Suzanne Kamel-Reid
| Journal of Clinical Pathology Verified
Lymphocyte maturation is a fascinating process marked by immunophenotypic changes, as well as discrete and regulated molecular events.1–3 For mature T cells, an important part of this molecular ‘evolution’ involves somatic alteration of the germline configuration of the T cell receptor (TCR) genes to a unique configuration, in order to permit development of a clone of T cells with an extracellular receptor specific to a given antigen.1–3 Modern diagnostic pathology has exploited the molecular...
Open in Who Shared Issue with article?
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