Thanmayi Ranganath on Muck Rack

Thanmayi Ranganath

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Articles

NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells

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By Nancy Zhao, Ruoxi Pi, David Nguyen, David Nguyễn, Thanmayi Ranganath
| biorxiv.org
Abstract Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4+ T cells in vitro.
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Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants - Nature Communications

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By Aaron J. Wilk, Thanmayi Ranganath, Mark Davis, Heather B. Jaspan, Catherine A. Blish
| Nature Verified
Abstract While preventing vertical HIV transmission has been very successful, HIV-exposed uninfected infants (iHEU) experience an elevated risk to infections compared to HIV-unexposed and uninfected infants (iHUU). Here we present a longitudinal multimodal analysis of infant immune ontogeny that highlights the impact of HIV/ARV exposure. Using mass cytometry, we show alterations in T cell memory differentiation between iHEU and iHUU being significant from week 15 of life.
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Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.

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By Sonwabile Dzanibe, Aaron James Wilk, Susan Canny, Thanmayi Ranganath
| biorxiv.org
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