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Thaomy T Vo

As seen in: BioRxiv
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Articles

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies

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By Meggie Danielson, Chris Nicolai, Thaomy T Vo, Natalie Wolf
| BioRxiv
Abstract Bacterial pathogens that invade the eukaryotic cytosol are distinctive tools for fighting cancer, as they preferentially target tumors and can deliver cancer antigens to MHC-I. Cytosolic bacterial pathogens have undergone extensive preclinical development and human clinical trials, yet the molecular mechanisms by which they are detected by innate immunity in tumors is unclear.
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Host glutathione is required for Rickettsia parkeri to properly septate, avoid ubiquitylation, and survive in macrophages.

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By Han Sun, Anh Luu, Meggie Danielson, Thaomy T Vo
| BioRxiv
Abstract Spotted fever group Rickettsia obligately reside in the cytosol where they parasitize over fifty metabolites from their hosts. However, the role for metabolite acquisition in pathogenesis remains unclear. Here, we find that depletion of the abundant low molecular weight thiol glutathione led to an impaired ability of Rickettsia parkeri to form plaques.
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