Thatcha Yimthin

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Yimthin T, Bourgeon M, Zhang J, Eggerschwiler L, Siegenthaler R, Schieck E, et al. (2025) Capsular polysaccharide of Mycoplasma mycoides subsp. capri contributes to phenotypic diversity promoting distinctive immune responses. PLoS Pathog 21(12): e1013386. https://doi.org/10.1371/journal.ppat.1013386 Editor: Mitchell F.

Abstract The Mycoplasma Immunoglobulin Binding/Protease (MIB-MIP) system is a candidate ‘virulence factor present in multiple pathogenic species of the Mollicutes, including the fast-growing species Mycoplasma feriruminatoris. The MIB-MIP system cleaves the heavy chain of host immunoglobulins, hence affecting antigen-antibody interactions and potentially facilitating immune evasion. In this work, using -omics technologies and 5’RACE, we show that the four copies of the M.

Abstract Although cattle are the mammalian species with most global biomass associated with a huge impact on our planet, their immune system remains poorly understood. Notably, the bovine immune system has peculiarities such as an overrepresentation of γδ T cells that requires particular attention, specifically in an infectious context. In line of 3R principles, we developed an ex vivo platform to dissect host-pathogen interactions.