Theesitha Srikanth on Muck Rack

Theesitha Srikanth

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Neonatal kidney injury in the hyperoxia-induced bronchopulmonary dysplasia mouse models: effect on morphology and biomarkers

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By Fred Graumuller, Divya Rajendran, Beamon Agarwal, Pragnya Das, Vineet Bhandari, Theesitha Srikanth, Xander Takada
| Nature
Abstract Preterm infants have reduced nephrons at birth and are exposed to hyperoxic environments. The objective was to examine the effects of hyperoxia on renal injury. We utilized a mouse model of experimental moderate (60% O2)-severe (100% O2) bronchopulmonary dysplasia (BPD), obtaining kidney tissue on postnatal day 14. The number of glomeruli, glomerulus length, and Bowman’s capsule’s length were recorded. Cell death and expression of multiple biomarkers were assessed.
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