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Thimea Trüpschuch on Muck Rack

Thimea Trüpschuch

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Articles

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation - Nature Communications

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By Laura Klement, Julia Drube, Stefan Schulz, Thimea Trüpschuch
| Nature Verified
Abstract G protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins. While most G protein functions are well-established, the contributions of GRKs and arrestins remain incompletely understood. Here, we investigate the influence of β-arrestin-interacting GPCR domains (helix-bundle/C-terminus) on β-arrestin conformations and functions using refined biosensors and advanced cellular knockout systems.
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