Thirsa Brethouwer on Muck Rack

Thirsa Brethouwer

As seen in: Nature
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Articles

Non-CG DNA methylation in animal genomes - Nature Genetics

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By Thirsa Brethouwer, Alex de Mendoza, Ozren Bogdanovic
| Nature Verified
Abstract Cytosine DNA methylation is widespread in animal genomes and occurs predominantly at CG dinucleotides (mCG). While the roles of mCG, such as in genomic imprinting and genome stability, are well established, non-CG DNA methylation (mCH) remains poorly understood. In most vertebrate tissues, roughly 80% of CGs are methylated, whereas mCH levels are generally low, typically ranging from 1% to 3%.
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A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation

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By Fan-Suo Geng, Gala Pujol, Estefanía Sanabria, Thirsa Brethouwer
| biorxiv.org
Abstract Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides a potential framework for inter- and transgenerational inheritance of gene-regulatory states. While extensively studied in mammals, our understanding of spermatogenesis in anamniotes remains limited.
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