Thomas Bardin

INTRODUCTION Calcium pyrophosphate deposition (CPPD) disease occurs as a consequence of the pathological presence of calcium pyrophosphate (CPP) crystals inside joints.1-4 It is an umbrella term comprising different acute and chronic phenotypes, which often coexist.5, 6 Acute CPP crystal arthritis presents with severe joint pain and swelling, like gout flares, commonly affecting knees, wrists, and ankles and lasting for several days to weeks.7-10 These episodes can be recurrent.

Abstract : This review re-examines the role of crystal deposition in the kidney in view of recent clinical and experimental findings. The involvement of the renal system in gout seems frequent. Indeed, recent studies showed that approximately 25% of patients with gout experience renal failure, defined by estimated glomerular filtration rate <60 mL/min/1.73 m2. The pathophysiology is complex and involves several factors, their respective roles being difficult to dissect.

Agathe Vigouroux1, Agnes Ostertag2, Anne-Claude Crémieux3,4, http://orcid.org/0000-0002-5080-4790Thomas Bardin1,2, http://orcid.org/0000-0002-1087-7768Augustin Latourte1,2, Hang-Korng Ea1,2, http://orcid.org/0000-0003-2132-4074Pascal Richette1,2 1 Service de Rhumatologie, AP-HP, Hôpital Lariboisière, Paris, France 2 Université de Paris, INSERM, UMR-S 1132 BIOSCAR, Paris, France 3 Infectiology Department, Hopital Saint-Louis, Paris, France 4 Université de Paris, FHU PROTHEE, Paris, France...