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Thomas Di Maio

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Articles by Thomas Di Maio

Multicentre validation of BRCAura, an AI-based histology model predicting germline BRCA1/2 mutations in HR+/HER2− breast cancer

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By Oussama Tchita, Elin Samuelsson, Damien Demont Jacobs, Katharina von Loga, Ross J. Hill, Gregory Rossi, Jack Rawson, Paraic A. Kenny, Javier Hernández-Losa, Sheeba Irshad, Ferroudja Daidj, Cécile Badoual Verified, Christine Lasset, Catherine Chassagne-Clément, Fabrice André, Ingrid Judith Garberis, Olivier Caron, Magali Lacroix-Triki, Axel Boulet, Estelle Hocquet, Thomas Di Maio, Thomas Holdbrook, Andrew Whittum, Séphora Campoy
| Nature Verified
Abstract Germline BRCA1/2 alterations (gBRCAm) are actionable drivers of breast cancer management, yet testing strategies based on clinical and family-history criteria miss many carriers. We developed BRCAura, a deep learning model that predicts gBRCAm status directly from routine histology whole-slide images.
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