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Thomas Dirk Lamme on Muck Rack

Thomas Dirk Lamme

As seen in: BioRxiv
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Articles

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

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By Omolade Otun, Roman R. Schlimgen, Thomas Dirk Lamme, Caitrin Crudden
| BioRxiv
Abstract Chemokine stimulation of atypical chemokine receptor 3 (ACKR3) does not activate G proteins but recruits arrestins. It is a chemokine scavenger that indirectly influences responses by restricting the availability of CXCL12, an agonist shared with the canonical receptor CXCR4. ACKR3 is upregulated in numerous disorders. Due to limited insights in chemokine-activated ACKR3 signaling, it is unclear how ACKR3 contributes to pathological phenotypes.
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CCR9 signal termination is governed by an arrestin-independent phosphorylation mechanism

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By Martine J. Smit, Christopher Schafer, Vrije Universiteit Amsterdam, Thomas Dirk Lamme
| BioRxiv
Abstract The chemokine receptor CCR9 coordinates immune cell migration from the thymus to the small intestine along gradients of CCL25. Receptor dysregulation is associated with a variety of inflammatory bowel diseases such as Crohns and ulcerative colitis, while aberrant CCR9 overexpression correlates with tumor metastasis. Despite being an attractive therapeutic target, attempts to clinically antagonize CCR9 have been unsuccessful.
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