Thomas H. Wesselink on Muck Rack

Thomas H. Wesselink

As seen in: Color Research & Application, Nature, Wiley, Science Magazine
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Articles

Hobit identifies tissue-resident memory T cell precursors that are regulated by Eomes

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By Felix Behr, Benjamin Nota, Thomas H. Wesselink, Loreto Parga-Vidal
| Science Magazine Verified
Tracing TRM roots Tissue-resident memory cells (TRM) established in peripheral tissues after initial antigen exposure are poised to rapidly respond upon reinfection. Parga-Vidal et al. used Hobit reporter/deleter mice to map the origin and differentiation of TRM cells during LCMV infection.
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Circulating memory CD8+ T cells are limited in forming CD103+ tissue‐resident memory T cells at mucosal sites after reinfection

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By Felix Behr, Thomas H. Wesselink, Ammarina Beumer‐Chuwonpad, Natasja A.M. Kragten
| Wiley Online Library Verified
Research Article Felix M.
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Tissue-resident memory CD8+ T cells shape local and systemic secondary T cell responses

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By Felix Behr, Thomas H. Wesselink, Ramon Arens, Regina Stark
| Nature Verified
Abstract Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse model exploiting the TRM-defining transcription factor homolog of Blimp-1 in T cells (Hobit) to fate map the TRM progeny in secondary responses.
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