Utilization of mp-MRI has been shown to be a valuable tool in the investigation of skeletal muscle pathology and the present study used mp-MRI to explore young adult mdx4cv mouse muscle pathology versus healthy age-matched controls. Previous studies have demonstrated that the cyclical changes occur in skeletal muscles of young dystrophic mice [17, 27]. However, these studies did not begin as early as 3 weeks of age nor used a multi-parametric characterization approach.