Thomas Magg

Mutated OAS1 leads to immunodeficiency Inborn errors of immunity can result in autoinflammatory immunodeficiencies. Type I interferon–inducible oligoadenylate synthetase 1 (OAS1) can initiate antiviral immune responses and is linked to pulmonary alveolar proteinosis with hypogammaglobulinemia. Here, Magg et al. identified four heterozygous OAS1 gain-of-function mutations that cause a polymorphic immunodeficiency in six patients.