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Thomas Zeffiro

As seen in: Nature, Blasting News, medRxiv
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Articles

Rapid antidepressant potential of nitrous oxide: current state and major questions - Molecular Psychiatry

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By Charles F. Zorumski, Yukitoshi Izumi, Thomas Zeffiro, Steven Mennerick, Peter Nagele
| Nature Verified
Abstract The success of ketamine, a dissociative anesthetic and non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, as a rapidly acting antidepressant has ignited efforts to identify other novel depression treatments.
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Nitrous Oxide Alters Functional Connectivity in Medial Limbic Structures in Treatment-Resistant Major Depression

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By Charles R. Conway, Thomas Zeffiro, Britt Gott, Frank Brown
| medRxiv
Abstract While nitrous oxide (N2O) has demonstrated antidepressant properties in treatment-resistant major depression (TRD), little is known about neural mechanisms mediating these effects. Employing serial resting-state functional magnetic resonance imaging (rsfMRI), we compared spatiotemporal effects of inhaled N2O on brain functional connectivity in TRD patients (n=14) and non-depressed healthy controls (n=16, CNTL).
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Spatial Network Connectivity and Spatial Reasoning Ability in Children with Nonverbal Learning Disability

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By Thomas Zeffiro, Amy Margolis, Sarah M. Banker, Bruce Ramphal
| Nature Verified
Abstract Nonverbal Learning Disability (NVLD) is characterized by deficits in visual-spatial, but not verbal, reasoning. Nevertheless, the functioning of the neural circuits supporting spatial processing have yet to be assessed in children with NVLD. We compared the resting state functional connectivity of a spatial brain network among children with NVLD, children with reading disorder (RD), and typically developing (TD) children.
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