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Thota Durga Devi on Muck Rack

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Differential Promoter Methylation of Macrophage Genes Is Associated With Impaired Vascular Growth in Ischemic Muscles of Hyperlipidemic and Type 2 Diabetic Mice

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By Mohan Babu, Thota Durga Devi, Petri Mäkinen, Minna Kaikkonen, Hanna P. Lesch, Sini Junttila, Asta Laiho, Bishwa Ghimire, Attila Gyenesei
| circres.ahajournals.org
Methods and Results: Unilateral hindlimb ischemia was induced by ligating femoral artery. Perfusion was assessed using ultrasound, and capillary and arteriole parameters were assessed using immunohistochemistry. Genome-wide methylated DNA sequencing was performed with DNA isolated from ischemic muscle, tissue macrophages (Mϕs), and endothelial cells.
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