Highlights • Mammalian NSCs utilize vimentin-caged aggresomes to recover proteostasis • Vimentin is required for proteasome localization to the aggresome in NSCs • Quiescent NSCs upregulate vimentin protein and utilize aggresomes during activation • Vimentin knockout in NSCs impairs proteostasis recovery and delays quiescence exit Summary Maintaining a healthy proteome throughout life is critical for proper somatic stem cell function, but the complexities of the stem cell response to...
