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Tian Yu Xie on Muck Rack

Tian Yu Xie

As seen in: Color Research & Application, Nature, Wiley Online Library, PLOS, Frontiers, MDPI, ACS Publications, Science Magazine, Royal Society of Chemistry, BioRxiv and
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Articles

Deep learning–guided engineering of SpuFz1 and rational miniaturization of ωRNA enables efficient genome editing

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By Shuanghong Chen, Shenlin Hsiao, Tian Yu Xie, Danni Chen, Naixin Chen, Jing Jiang, Jinsong Li, Yuxuan Wu, Jiaoyang Liao
| Nature Verified
Abstract Advancing the performance of programmable genome editing nucleases remains a key challenge in expanding their research and therapeutic applications. Here, we introduce a scalable deep learning–guided protein engineering framework for improving nuclease activity without requiring experimental training data.
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Endothelial SP1 lactylation promotes bronchopulmonary dysplasia via regulation of Cdkn1a expression

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By Ziming Zhang, Qiqi Li, Lingchen Li, Tian Yu Xie, Mengting Hu, Yun Ling, Lingling Yan, Tieshuai Liu, Xiaolu Ma, Zheng Chen, Jiajun Zhu, Jia He, Wei Shi, Lizhong Du, Xinmin Ju, Lu Zu, Qianyun Cao, Jiajing Ge
| Nature Verified
Abstract Bronchopulmonary dysplasia (BPD) is a major complication of prematurity, and endothelial dysfunction contributes to its pathogenesis. Although lactate metabolism is dysregulated in BPD, whether lactate-derived lysine lactylation contributes to endothelial dysfunction remains unknown. This study investigated the role of lactylation in endothelial injury and the involvement of SP1-Cdkn1a axis in BPD.
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Does Seed Coating Technology Derived From Agricultural Production Hold Promise for Ecological Restoration?

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By Tian Yu Xie, Wenhao Lu, Yongning Ren
| Wiley Online Library Verified
1 Introduction Seed germination and seedling establishment constitute pivotal ecological processes that underpin global food security and ecosystem resilience. While agricultural civilizations have long enhanced seeds to boost crop yields, today's widespread ecosystem degradation—driven by climate change, habitat loss, and soil deterioration—now demands that these technologies extend beyond farmland to support the restoration of damaged natural ecosystems (Rajjou et al., 2012; Roberts, 2012).
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