Tianshi Que on Muck Rack

Tianshi Que

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Articles

Hypoxia-induced circSPECC1 drives temozolomide resistance in glioblastoma via IGF2BP2-mediated PGK1 mRNA stabilization

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By Yu Zeng, Liqian Zhao, Li Zhou Verified, Xiaosheng Yang, Xin Xu, Kaihua Cao, Xizhao Wang, Xuhui Wang, Wenchuan Zhang, Ming Chen, Tianshi Que
| Nature Verified
Abstract Glioblastoma (GBM) is a notoriously lethal brain tumor, primarily owing to its inevitable resistance to temozolomide (TMZ), a frontline chemotherapy. Hypoxia-driven metabolic adaptations have been implicated in therapeutic failure; however, the role of circular RNAs remains largely underexplored.
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