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An Iridium(III) Complex Induces Immunogenic Methuosis and Reprograms Tumor-Associated Macrophages for Chemoimmunotherapy against KRAS-Mutated Tumors Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 12, 2026 An Iridium(III) Complex Induces Immunogenic Methuosis and Reprograms Tumor-Associated Macrophages for Chemoimmunotherapy against KRAS-Mutated Tumors Click to copy article linkArticle link copied! Zhuoli Chen Zhuoli Chen MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510006, P. R.
Nutzung der immunogenen PANoptose mit Iridium(III)-Biradikal-Photosensibilisatoren für die Photoimmuntherapie des Melanoms
Die Effektivität der photodynamischen Therapie (PDT) wird wesentlich durch einen intrinsischen photophysikalischen Konflikt zwischen den beiden ROS-generierenden Mechanismen eingeschränkt. Typ-I-Prozesse erfordern einen stark reduzierenden angeregten Zustand, um Elektronentransferreaktionen zu ermöglichen, während Typ-II-Prozesse einen langlebigen Triplettzustand benötigen, um eine effiziente Energietransferreaktion auf molekularen Sauerstoff zu gewährleisten.
Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie73467-sup-0001-SuppMat.docx13.3 MB Supporting File: anie73467-sup-0001-SuppMat.docx. References 1, , , et al., “Photodynamic Therapy of Cancer: An Update,” CA: A Cancer Journal for Clinicians 61 (2011): 250–281, https://doi.org/10.3322/caac.20114.
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