Tibély Gergely

Abstract Tumors often harbor orders of magnitude more mutations than healthy tissues. The increased number of mutations may be due to an elevated mu- tation rate or frequent cell death and correspondingly rapid cell turnover, or a combination of the two. It is difficult to disentangle these two mech- anisms based on widely available bulk sequencing data, where sequences from individual cells are intermixed and, thus, the cell lineage tree of the tumor cannot be resolved.