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Tiebao Meng

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Articles

Targeting tumour–neuron synapses with intracavitary RNA delivery prevents glioblastoma recurrence

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By Zhi Li, Zhao-Zhe Hao, Yihe Zhang, Nana Xu, Haokun Jiao, Cong Wang, Furong Chen, Yuan Xie, Changyu Wang, Meiqin Tang, Hao Duan, Jing L. Wang, HaoQiang He, Nannan Bai, Chuanmiao Xie, Ruiwang Huang, Zhenqiang He, Sheng Liu, Yonggao Mou, Tiebao Meng, Huilong Guo
| Nature Verified
Abstract Tumour–neuron interactions and malignant synapse formation drive glioblastoma progression, recurrence and neurological dysfunction, but systemic inhibition of synaptic signalling causes unacceptable neurotoxicity. Here we defined the spatial and molecular determinants of malignant synapses by analysing intact human glioblastoma specimens, revealing enrichment of synapse-like structures and synapse-associated gene programmes at the tumour–brain interface.
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