Tien-Chye Tan on Muck Rack

Tien-Chye Tan

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Articles

Structural basis for dolichylphosphate mannose biosynthesis

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By Rosaria Gandini, Tom Reichenbach, Tien-Chye Tan, Christina Divne
| Nature Verified
We determined the crystal structures of PfDPMS in complex with metal-bound nucleotide (GDP•Mg2+) and donor (GDP-Man•Mn2+; Supplementary Table 1). The overall structure of PfDPMS features an N-terminal, cytoplasmic catalytic domain covalently attached to a TM domain with four TM helices (TMHs) arranged as two TMH dimers, TMD1 and TMD2 (Fig. 1).
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