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Dynamics of SARS-CoV-2 VOC Neutralization and Novel mAb Reveal Protection against Omicron
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SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function
Highlights • SARS-CoV-2 selectively infects hPSC-CMs via ACE2, and replicates at high-copy number. • SARS-CoV-2 enters hPSC-CMs via endocytosis and fusion, and egresses using lysosomes. • SARS-CoV-2 alters gene expression of hPSC-CMs in a dose- and time-dependent manner. • Electrophysiological and contraction properties decline during SARS-CoV-2 infection.
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