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Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model

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By Nick van Osta, Aurore Lyon, Feddo Kirkels, Tijmen Koopsen
| royalsocietypublishing.org
1. Introduction Arrhythmogenic cardiomyopathy (AC) is an inherited cardiomyopathy, clinically characterized by the occurrence of ventricular arrhythmias, sudden cardiac death (SCD) and predominantly right ventricular (RV) dysfunction [1,2]. A pathogenic genetic mutation, mostly affecting desmosomal genes, is found in up to 60% of probands.
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