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Novel drug development in the fight against the HIV pandemic Despite incredible advances in treatment, there is still no cure or vaccine for human immunodeficiency virus (HIV), and the disease persists as a global pandemic to this day. According to the World Health Organization, the number of people living with HIV has risen to 39.9 million worldwide (as of 2023), with 1.3 million people acquiring HIV in the past year alone.
As developers of lentiviral vector (LVV)-based cell and gene therapies continue to innovate, the demand for high-quality LVV is expected to rise significantly. This growing need necessitates advanced characterization techniques that can enable process development, providing improved performance, efficacy, and safety.
Arnold J. Mahamid J. Lucic V. de Marco A. Fernandez J.J. Laugks T. Mayer T. Hyman A.A. Baumeister W. Plitzko J.M. Site-Specific Cryo-focused Ion Beam Sample Preparation Guided by 3D Correlative Microscopy. Biophys. J. 2016; 110: 860-869 Asano S. Engel B.D. Baumeister W. In Situ Cryo-Electron Tomography: A Post-Reductionist Approach to Structural Biology. J. Mol. Biol. 2016; 428: 332-343 Aseeva E. Ossenbühl F. Eichacker L.A. Wanner G. Soll J.
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