Till Bartke

At the Institute of Functional Epigenetics (IFE), we aim to uncover how epigenetic information is stored and how the environment controls our epigenome to identify novel therapeutic targets. At the Institute of Functional Epigenetics (IFE), we aim to uncover how epigenetic information is stored and how the environment controls our epigenome to identify novel therapeutic targets.

As hepatocytes are the main site of BA activity, we initially undertook RNA sequencing (RNA-seq) analyses of primary mouse hepatocytes treated with BA (Figures S1A and S1B). Our data revealed a strong activation of PPAR signaling, fatty acid degradation, and retinol metabolism pathways (Figure 1A). To extend our findings to animal models, we treated lean mice and mice with obesity with BA for 4 weeks (Figures S1C and S1D).

Abstract Intrinsically disordered regions (IDRs) pervasively engage in essential molecular functions, yet they are often poorly conserved as assessed by sequence alignment. To explore the seeming paradox of how sequence variability is compatible with persistent function, we examined the functional determinants for a poorly conserved but essential IDR. We show that IDR function depends on two distinct but related properties: sequence and chemical specificity.