Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Tim Kong
Unraveling TIME: CD8+ T cell– and CXCL11-driven endocrine resistance in breast cancer
Abstract A major unmet need in estrogen receptor–positive (ER+) breast cancer is understanding the mechanisms that underlie resistance to endocrine therapy. Although accumulating evidence suggests an association between the tumor immune microenvironment (TIME) and endocrine response, the specific role of the TIME in mediating endocrine resistance remains unclear. In this issue of the JCI, Napolitano et al.
Biomarkers of response to neoadjuvant palbociclib plus anastrozole in endocrine-resistant estrogen receptor-positive/HER2-negative breast cancer: a phase 2 trial | Nature Communications
Abstract CDK4/6 inhibitors (CDK4/6i) improve outcomes for estrogen receptor (ER) positive/HER2-negative breast cancers (BCs), yet intrinsic and acquired resistance exist. Here, we evaluated anastrozole in combination with palbociclib (ANA/PAL) in the NeoPalAna Endocrine-Resistant cohort (NCT01723774).
RSK1 is an exploitable dependency in myeloproliferative neoplasms and secondary acute myeloid leukemia - Nature Communications
Abstract Myeloid malignancies are heterogenous disorders characterized by distinct molecular drivers but share convergence of oncogenic signaling pathways and propagation by ripe pro-inflammatory niches. Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes.
RSK1 dependency in FLT3-ITD acute myeloid leukemia - Blood Cancer Journal
Abstract Internal tandem duplications (ITD) in fms-like tyrosine kinase 3 (FLT3) represent the most common genetic alteration in de novo acute myeloid leukemia (AML). Here, we identify ribosomal protein s6 kinase a1 (RSK1) as a core dependency in FLT3-ITD AML and unveil the existence of crucial bi-directional regulation. RSK1 perturbation resulted in marked apoptosis and abrogated phosphorylation of FLT3 and associated downstream signaling cascades in FLT3-ITD AML cell lines.
Multiomic profiling reveals metabolic alterations mediating aberrant platelet activity and inflammation in myeloproliferative neoplasms
ResearchHematology Open Access | 10.1172/JCI172256 J Clin Invest. https://doi.org/10.1172/JCI172256. Copyright © 2023, He et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Platelets from patients with myeloproliferative neoplasms (MPNs) exhibit a hyperreactive phenotype.
Comprehensive profiling of clinical JAK inhibitors in myeloproliferative neoplasms
Abstract Small molecule inhibitors targeting JAK2 provide symptomatic benefits for myeloproliferative neoplasm (MPN) patients and are among first-line therapeutic agents. However, despite all having potent capacity to suppress JAK–STAT signaling, they demonstrate distinct clinical profiles suggesting contributory effects in targeting other ancillary pathways.
DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression - Nature Cancer
Abstract Myeloproliferative neoplasms (MPNs) exhibit a propensity for transformation to secondary acute myeloid leukemia (sAML), for which the underlying mechanisms remain poorly understood, resulting in limited treatment options and dismal clinical outcomes. Here, we performed single-cell RNA sequencing on serial MPN and sAML patient stem and progenitor cells, identifying aberrantly increased expression of DUSP6 underlying disease transformation.
Be Strong. Be Kind.
The drive to lift and shift the "business as usual" of public education into the home as a result of COVID-19 and potential lock-down situations is a completely broken and shameful response to the reality of these times By any measure, these are extraordinary times.
CD44 Promotes PD-L1 Expression and Its Tumor-Intrinsic Function in Breast and Lung Cancers
Molecular Cell Biology Tim Kong, Ryuhjin Ahn, Kangning Yang, Xianbing Zhu, Zheng Fu, Geneviève Morin, Rachel Bramley, Nikki C. Cliffe, Yibo Xue, Hellen Kuasne, Qinghao Li, Sungmi Jung, Anne V. Gonzalez, Sophie Camilleri-Broet, Marie-Christine Guiot, Morag Park, Josie Ursini-Siegel and Sidong Huang DOI: 10.1158/0008-5472.CAN-19-1108 Published February 2020 This article requires a subscription to view the full text.
CD44 promotes PD-L1 expression and its tumor-intrinsic function in breast and lung cancers
Research Article Tim Kong, Ryuhjin Ahn, Kangning Yang, Xianbing Zhu, Zheng Fu, Geneviève Morin, Rachel Bramley, Nikki C Cliffe, Yibo Xue, Hellen Kuasne, Qinghao Li, Sungmi Jung, Anne V Gonzalez, Sophie Camilleri-Broët, Marie-Christine Guiot, Morag Park, Josie Ursini-Siegel and Sidong Huang DOI: 10.1158/0008-5472.CAN-19-1108 Abstract The PD-L1 (CD274) immune checkpoint ligand is often upregulated in cancers to inhibit T cells and elicit immunosuppression.
on capes and cliffs
It's January first - the day in which we're all meant to start new, feel free of the last year, and boldly look to the next. But I'm struggling, still exhausted from the end of last year at my place. Worried for myself and what that lifestyle choice actually means for me. There has been many times this year, where despite the stress and confusion, I've felt capable of saying "I've got this - I can do this - I can be a leader in a school".
A slice of a Twitter story...
This came across my timeline tonight. And I was struck by what a fantastic opportunity it'd be for a teacher to place this tweet in front of students with some challenge questions. As someone who's no longer in a classroom, I'm probably not following all the "proper" ways of aligning tasks with recognised assessment methods - but I love the small but incredible story captured in this one tweet - and see it as a fantastic way of expanding student's horizons.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Tim
Contact Tim, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack