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Timea Boroczky on Muck Rack

Timea Boroczky

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Single-cell light-sheet fluorescence 3D images of tumour-stroma spheroid multicultures

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By Akos Diosdi, Filippo Piccinini, Gabriella Dobra, Gastone Castellani, Peter Horvath, Mária Harmati, Timea Boroczky, Krisztina Buzas
| Nature Verified
Abstract Spheroids are widely used in oncology for testing drugs, but models composed of a single cell line do not fully capture the complexity of the in vivo tumours targeted by chemotherapy. Developing 3D in vitro models that better mimic tumour architecture is a crucial step for the scientific community. To enable more reliable drug testing, we generated multiculture spheroids and analysed cell morphology and distribution over time.
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