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Tímea Margit Szabó on Muck Rack

Tímea Margit Szabó

As seen in: Nature, Wiley Online Library, MDPI
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Articles

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment - Nature Communications

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By Zhuoyao Chen, Timea Balo, Xiangrong Chen, Steven Clifford, Vincenzo D’Angiolella, Timea Magdolna Szabo, Tímea Margit Szabó, András Herner
| Nature Verified
Abstract Neomorphic mutations and drugs can elicit unanticipated effects that require mechanistic understanding to inform clinical practice. Recurrent indel mutations in the Kelch domain of the KBTBD4 E3 ligase rewire epigenetic programs for stemness in medulloblastoma by recruiting LSD1-CoREST-HDAC1/2 complexes as neo-substrates for ubiquitination and degradation.
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Bifunctional Sildenafil Diazeniumdiolates Acting as Phosphodiesterase 5 Inhibitors and Nitric Oxide Donors− Towards Wound Healing

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By Josep Mas-Roselló, Hermann Tenor, Timea Magdolna Szabo, Tímea Margit Szabó, Reto Naef
| Wiley Online Library Verified
Introduction Inefficient wound healing is a common problem affecting millions of people worldwide each year.1 Factors such as aging, infections, vascular insufficiency, and diabetes mellitus contribute to impaired healing.2 These often result in chronic skin defects, such as ulcers, which in the most severe cases can potentially require the amputation of the affected extremity.
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Genes | Free Full-Text | Helsmoortel-Van der Aa Syndrome-Cardiothoracic and Ectodermal Manifestations in Two Patients as Further Support of a Previous Observation on Phenotypic Overlap with RASopathies

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By Tímea Margit Szabó, István Balogh, Anikó Ujfalusi, László Madar
| MDPI
Open AccessCase Report by Tímea Margit Szabó 1,*, István Balogh 2, Anikó Ujfalusi 2, Zsuzsanna Szűcs 2, László Madar 2, Katalin Koczok 2, Beáta Bessenyei 2, Ildikó Csürke 3 and Katalin Szakszon 1 1 Institute of Paediatrics, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary 2 Division of Clinical Genetics, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary 3 Jósa András Hospital, Szabolcs-Szatmár-Bereg County Hospitals and...
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