Timothy Hendrickson

Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Brain function and structure are known to be affected by environmental conditions. Marek et al. mapped brain-wide association studies (BWAS) of 649 phenotypes and exposures to brain function and structure using imaging data from many sources (see the Perspective by Sisk and Satterthwaite).

Abstract Reproducibility of neuroimaging research on infant brain development remains limited due to highly variable processing approaches. Progress towards reproducible pipelines is limited by a lack of benchmarks such as gold-standard brain segmentations. These segmentations are limited by the difficulty of infant brain segmentations, which require extensive neuroanatomical knowledge and are time-consuming in nature.

Abstract Objectives: Brain segmentation of infant magnetic resonance (MR) images is vitally important for studying typical and atypical brain development. The infant brain undergoes many changes throughout the first years of postnatal life, making tissue segmentation difficult for most existing algorithms.