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The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: The study was approved by Houston Methodist Research Institute under the transplant center data analysis institutional review board protocol Pro00000587.
Abstract Alternative splicing is a pervasive mechanism that expands the coding potential and functional complexity of the human genome. Dysregulated isoform usage alters gene functions and contributes broadly to human disease across developmental, neurodegenerative, and cancer settings.
Cancer cell line and tumor tissue samples All research activities of this study comply with relevant ethical regulations of Northwestern University Institutional Biomedical Review Board. The A375 cell line was provided by Dr. Michael A. Davies at MD Anderson Cancer Center, and H2030 was obtained from the Antibody and Bioresource Core Facility at Memorial Sloan Kettering. The cell lines are standard commercialized cancer lines.
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