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Tinghong Zhang

As seen in: Nature, ACS Publications
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Articles

Hijacking innate immunity to enhance mRNA therapeutics by blocking IFN-P-body-XRN1 axis-mediated degradation

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By Tinghong Zhang, Xing Peng, Jinling Qin, Shuaihua Zhang, Shijie Deng, Zhimin Song, Yulong Han, Hui Zheng, Jingjing Chen, Yun Zhang, Yaofeng Wang, Jingyuan Zhang, Yumin Zhou, Pixin Ran, Ningyi Shao, Bin Zhu, Shu Meng, Binqiang Zhu, Yunshen Chan
| Nature Verified
Abstract Innate immune activation is a major driver of unmodified in vitro–transcribed (IVT) mRNA degradation; however, how modified IVT mRNAs are degraded, and the related regulation mechanisms, remain poorly understood. Through a focused screen of viral- and host-derived immune suppressors, we identify 13 factors that enhance mRNA performance, with SOCS1 and the coronaviral membrane protein (M) emerging as the most potent.
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MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice

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By Xiyang Wei, Shicheng Yu, Tinghong Zhang, Liansheng Liu
| dx.doi.org
The intestinal epithelium has an ability to regenerate rapidly in response to various types of damage. (1) This regenerative capacity is regulated by multiple stem and progenitor populations found in the intestinal crypts. (2,3) ISCs are vital for maintaining the intestinal epithelium’s homeostasis by generating all cell types along the crypt-villi axis.
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Hexahistidine-Metal Assemblies: A Facile and Effective Codelivery System of Subunit Vaccines for Potent Humoral and Cellular Immune Responses

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By Tinghong Zhang, Long Zhang, Xiaoxiao Wu, Hongyan Xu
| ACS Publications
Download Hi-Res ImageDownload to MS-PowerPointCite This:Mol. Pharmaceutics 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Tinghong Zhang Tinghong Zhang School of Ophthalmology and Optometry, Eye Hospital, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325035, P. R. China Wenzhou Institute, University of Chinese Academy of Sciences (Wenzhou Institute of Biomaterials & Engineering), Wenzhou 325001, P. R.
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