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Tingshan Wu on Muck Rack

Tingshan Wu

As seen in: BioRxiv
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Articles

Somatic Transthyretin-Related Proteins in C. elegans Govern Reproductive Longevity by Sustaining Sperm Integrity and Timely Ovulation

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By Haochen Lyu, Zhao Wang, Zhaoyang Jiang, Tingshan Wu
| BioRxiv
Abstract The decline in reproductive capability during adult life is critical for health, but its mechanism is elusive. We systematically analyzed the developmental role of an expanded TTR family of proteins, structurally analogous to mammalian thyroid hormone-transporting Transthyretin, and identified three paralogous proteins, TTR-15, TTR-16, and TTR-17, differentially expressed in somatic cells of the gonads and secreted around gametes in C. elegans.
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