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Tingze Feng on Muck Rack

Tingze Feng

As seen in: Nature
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Articles

Identifying potential combinatorial mechanism between paclitaxel and Almonertinib in lung cancer through multi-omics integration

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By Yiqian Wang, Jing Lv, Qiuping Wang, Shaojun Pei, Tingze Feng, Hailong Piao, Di Chen, Ji-Wei Liu
| Nature Verified
Abstract Combination therapy using epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and cytotoxic chemotherapy is a promising strategy to overcome resistance in non-small cell lung cancer (NSCLC). However, the complicated molecular mechanisms remain elusive. Here, we employed an integrated multi-omics approach to dissect the molecular responses to the third-generation EGFR-TKI Almonertinib (Alm) and paclitaxel (PTX) and their combination in EGFR-mutant NSCLC cells.
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