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Tirso Pons

As seen in: Science Magazine, BioRxiv
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Articles

Diacylglycerol kinase ζ in B lymphocytes supports CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell fate

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By Ana Fernandez-Barrecheguren, Zhichuan Zhu, Wei Wong Verified, Adrian Fernandez-Rego, Lucia Fuentes-Cantos, Tirso Pons, Belén Estrada, Marta Iborra-Pernichi, María de la Esperanza, Tahmineh Ebrahimi, Ana Sagrega-Aparisi, Sara Cogliati, Nuria Martinez-Martin, Rodrigo Jiménez-Saiz, Yolanda R. Carrasco
| Science Magazine Verified
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Stimulation of the receptor CD40 on B cells by its ligand on T follicular helper cells drives B cell activation, antibody production, and memory cell generation. Fernández-Barrecheguren et al. showed that the kinase DGKζ mediated CD40 signaling in mouse B cells both as a kinase and as an adaptor.
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Diacylglycerol kinase zeta dictates CD40-mediated immune synapse formation, mTORC1 signaling and plasma cell fate in B lymphocytes

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By Tirso Pons, Ana Fernandez-Barrecheguren, Adrian Fernandez-Rego, Lucia Fuentes-Cantos
| BioRxiv
Abstract To mount a robust T-dependent immune response, antigen-specific B lymphocytes require CD40 stimulation through immune synapse formation with CD4+ T follicular helper cells. CD40 triggers the activation of mammalian target of rapamycin complex-1 (mTORC1) and remodels the mitochondria to meet increased bioenergetic and anabolic demands.
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The chromatin reader Dido3 is a regulator of the gene network that controls B cell differentiation

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By Tirso Pons, Ricardo Arveras Villares, Maria Angeles Garcia-Lopez, Carlos Martinez-A
| BioRxiv
Abstract The development of hematopoietic cell lineages is a highly complex process that is governed by a delicate interplay of various transcription factors. The expression of these factors is influenced, in part, by epigenetic signatures that define each stage of cell differentiation. In particular, the formation of B lymphocytes depends on the sequential silencing of stemness genes and the balanced expression of interdependent transcription factors, along with DNA rearrangement.
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