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Articles by Todd Le
Optical Coherence Tomography Patterns in the Molecular Diagnosis and Treatment Response of Port Wine Capillary Malformations (Port Wine Birthmarks)
1 Introduction Port wine capillary malformations (PWCMs) represent a diagnostic grouping of genetically diverse vascular anomalies which present at birth as light pink to purple vascular patches on the skin and progressively darken with time. Nearly all PWCMs are caused by mosaic activating variants in genes that regulate cell growth, vascular homeostasis, and fetal vasculature development.
Adding to Your Tool Box: Laser Therapy for Vascular Anomalies
1 Introduction Vascular anomalies (VA) are a diverse set of disorders that cumulatively affect 7–8% of the population, represent developmental disorders of the vasculature, and range from vascular staining of the skin to debilitating overgrowth, tumors, and abnormalities of soft tissue, bone, muscle, brain, and eye [1]. These lesions are slowly progressive, cosmetically disfiguring, and may be associated with life-threatening, multi-organ disease.
Dupilumab in the Treatment of Pemphigoid Gestationis
Pemphigoid gestationis (PG), which manifests in the second or third trimester of pregnancy, is thought to result from an excessive type 2 inflammatory response that leads to the formation of antibodies primarily targeting BP180 antigens with resultant damage to the skin basement membrane.1 Maternal antibodies can be transferred to the fetus, resulting in neonatal pemphigoid with the development of widespread vesicles and bullae.2 Maternal morbidity from placental insufficiency, intrauterine...
Micronutrient Deficiencies in Patients With Inflammatory Bowel Disease
In 2023, ESPEN (the European Society for Clinical Nutrition and Metabolism) published consensus recommendations highlighting the importance of regular monitoring and treatment of nutrient deficiencies in patients with inflammatory bowel disease (IBD) for improved prognosis, mortality, and quality of life.1 Suboptimal nutrition in patients with IBD predominantly results from inflammation of the gastrointestinal (GI) tract leading to malabsorption; however, medications commonly used to manage...
Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus
Key Points Question Is there an association between neighborhood measures of deprivation and disease severity in discoid lupus erythematosus (DLE)? Findings In this cross-sectional study of 154 adult patients with DLE from the Philadelphia, Pennsylvania, area, residence in census blocks with a higher area deprivation index score was associated with more severe DLE disease activity and damage.
Micronutrient Deficiencies in Patients With Inflammatory Bowel Disease
Publish date: April 8, 2024 Inflammatory bowel disease (IBD) can cause micronutrient deficiencies that have cutaneous manifestations. Dermatologists may be the first to identify an undiagnosed micronutrient deficiency in the affected population. The approach to monitoring and repleting a micronutrient deficiency may be impacted by factors such as IBD activity and potential interactions between supplements and medications used to treat IBD.
Anifrolumab for Adolescent Discoid Lupus Erythematosus
Anifrolumab for Adolescent Discoid Lupus Erythematosus Introduction Anifrolumab, a human monoclonal antibody targeting type I interferon receptor, was approved in 2021 for adults with systemic lupus erythematosus (SLE) and has since emerged as an efficacious agent for refractory discoid lupus erythematosus (DLE).1 Rapid clinical improvement has been attributed to anifrolumab’s selective antagonism of type I interferon signaling, a known factor associated with DLE disease activity.2 However,...
Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus
Ayuda Buscar en la ayuda Buscar en la ayuda Area Deprivation and Disease Severity in Adult Patients With Discoid Lupus Erythematosus Autores: Daniella Forman Faden, Lillian Xie, Caroline Stone, Lais Lopes Almeida Gomes, Todd Le, Nnenna Ezeh, William R. Buckingham, Amy Kind, Ruth Ann Vleugels, Victoria P. Werth, Lisa Arkin, Katharina S. Shaw Localización: JAMA Dermatology, ISSN 2168-6068, Vol. 160, Nº. 9, 2024, págs.
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