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Articles by Todd W. Wisner
Characterization of the Herpes Simplex Virus (HSV) Tegument Proteins That Bind to gE/gI and US9, Which Promote Assembly of HSV and Transport into Neuronal Axons
Virus-Cell Interactions | Spotlight Grayson DuRaine, Todd W. Wisner, David C. Johnson Felicia Goodrum, Editor DOI: 10.1128/JVI.01113-20 ABSTRACT The herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks the assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV virions do not enter axons.
Characterization of the herpes simplex virus tegument proteins that bind to gE/gI and US9, which promote assembly of HSV and transport into neuronal axons
Virus-Cell Interactions Grayson DuRaine, Todd W. Wisner, David C. Johnson DOI: 10.1128/JVI.01113-20 ABSTRACT Herpes simplex virus (HSV) heterodimer gE/gI and another membrane protein US9, which has neuron-specific effects, promote anterograde transport of virus particles in neuronal axons. Deletion of both HSV gE and US9 blocks assembly of enveloped particles in the neuronal cytoplasm, which explains why HSV virions do not enter axons.
Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons
ABSTRACTHerpes simplex virus (HSV) and other alphaherpesviruses must spread from sites of viral latency in sensory ganglia to peripheral tissues, where the viruses can replicate to higher titers before spreading to other hosts. These viruses move in neuronal axons from ganglia to the periphery propelled by kinesin motors moving along microtubules.
Human Cytomegalovirus gH/gL Forms a Stable Complex with the Fusion Protein gB in Virions
Loading metrics Open Access Peer-reviewed Research Article Adam L. Vanarsdall , Paul W. Howard, Todd W. Wisner, David C. Johnson Adam L. Vanarsdall, Paul W. Howard, Todd W. Wisner, David C. Johnson Published: April 15, 2016 https://doi.org/10.1371/journal.ppat.1005564 Abstract Human cytomegalovirus (HCMV) is a ubiquitous virus that is a major pathogen in newborns and immunocompromised or immunosuppressed patients.
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