Tofazzal Md Rakib

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The authors have nothing to report. References 1, , and , “ Chapter Five - Arboviruses Pathogenic for Domestic and Wild Animals,” in Advances in Virus Research, eds. K. Maramorosch and F. A. Murphy, (Academic Press, 2014), 201–275.

Abstract Paramyxovirus polymerase recognizes an RNA editing signal on the viral genome and transcribes mRNA in which guanine nucleotides are inserted in a template-independent manner. This enables the synthesis of multiple proteins from a single gene, which is important for viral growth. We developed a method to quantify RNA editing efficiency using Oxford Nanopore Technologies' MinION platform.

Abstract Paramyxovirus genomes carry bipartite promoters at the 3' ends of both their genome and antigenome, thereby initiating RNA synthesis, which requires the viral polymerase to recognize two elements: the primary promoter element 1 (PE1) and the secondary promoter element 2 (PE2). We have previously shown that the antigenomic PE2 (agPE2) in many viruses in the Rubulavirinae subfamily is located within the coding region of the viral RNA polymerase L gene.