Tohru Fujiwara

Abstract Erythropoiesis, i.e., process of red blood cell (RBC) production, is highly dependent on iron, with 60–70% of the total body iron incorporated into hemoglobin. Iron homeostasis is tightly regulated, given that both iron overload and deficiency can impair RBC development and function. Iron-loading anemias, such as sideroblastic anemia and thalassemia, are associated with ineffective erythropoiesis and systemic iron overload.

Research Article Kei Saito, Tohru Fujiwara, Shunsuke Hatta, Masanobu Morita, Koya Ono, Chie Suzuki, Noriko Fukuhara, Yasushi Onishi, Yukio Nakamura, Shin Kawamata, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae DOI: 10.1128/MCB.00387-18 ABSTRACT Ring sideroblasts are a hallmark of sideroblastic anemia, although little is known about their characteristics.